Pharmacology and Therapeutics MCQ I

Question 1 of 100

1. Question

Diloxanide furoate: Which of the statements below is correct?

It is the drug of choice for hepatic amebiasis.
500mg 8 hourly for 10 days adequately treats adults with luminal amebiasis.
It is given as 5mg/kg/day in three divided doses for one week to children.
It should not be used for carriers of Entamoeba histolytica cysts.

Question 2 of 100

2. Question

Tinidazole: Which of the statements below is correct?

It is similar to emetine structurally.
It is ineffective in treating amoebic colitis.
When administered as 2g orally daily for three days, it appropriately treats giardiasis.
The pediatric dose is 50mg/kg once for trichomoniasis.

Question 3 of 100

3. Question

Which of the following is not a side effect of Niridazole?

Insomnia.
Headache.
Paresthesias.
Constipation.

Question 4 of 100

4. Question

Benzodiazepines: Which of the statements below is correct

They cannot be used in depressed patients who show evidence of anxiety.
They are very effective in schizophrenia.
They are useful anticonvulsants.
They may be conveniently taken by a commercial driver before the day’s duty.

Question 5 of 100

5. Question

Which of the following is an unlikely side effect of phenytoin?

Diarrhea.
Restlessness.
Gingival hypertrophy.
Rashes.

Question 6 of 100

6. Question

Triprolidine hydrochloride and pseudo-ephedrine combination: Which of the statements below is correct?

It is beneficial in lower respiratory tract disorders.
It has an antitussive action.
It does not cause drowsiness.
It causes nasal congestion.

Question 7 of 100

7. Question

Narcotic analgesics do not include which of the following drugs?

Pethidine.
Naloxone.
Codeine.
Meperidine.

Question 8 of 100

8. Question

Amebiasis may not be treated with which of the following drugs?

Tinidazole.
Ampicillin.
Diloxanide furoate.
Secnidazole.

Question 9 of 100

9. Question

Which of the following statements about Mebendazole is correct?

It is a benzoimidazole derivative.
It acts by inhibiting DNA synthesis in helminths.
It is available as 25mg tablets.
It is given to adults in a dose of 100mg twice daily for two days for hookworm disease.

Question 10 of 100

10. Question

Niridazole is used for the treatment of which of the following?

Schistosomiasis.
Paragonimiasis.
Hookworm disease.
Hymenolepiasis.

Question 11 of 100

11. Question

Diazepam: Which of the statements below is correct?

It is lightly bound to protein.
It does not undergo hydroxylation.
When taken on three-times-a-day basis over a two-week period, it does not result in accumulation.
It leads to habituation with prolonged use of relatively high doses.

Question 12 of 100

12. Question

Digoxin: Which of the statements below is correct?

It causes tachycardia in therapeutic doses.
Its effect is potentiated by hypokalemia.
It decreases myocardial contractility.
It decreases stroke volume.

Question 13 of 100

13. Question

Which of the following statements is incorrect?

Codeine is an antitussive agent.
Bromhexine causes dissolution of bronchial mucus.
Pseudo-ephedrine is a nasal decongestant.
Xylometazoline is a beta blocker.

Question 14 of 100

14. Question

Which of the following statements is correct?

Concurrent use of morphine and phenothiazines increases the chances of hypertension.
Chlorpromazine does not affect narcotic analgesia when used by the same patient.
Cocaine potentiates morphine analgesia.
Nalorphine is a morphine agonist

Question 15 of 100

15. Question

Which of the following statements about emetine is incorrect?

It is useful in treating patients with severe vomiting.
It is available in injection form.
Hypotension is a known side effect.
T-wave flattening is a known ECG finding in emetine toxicity

Question 16 of 100

16. Question

Mebendazole is ineffective for the treatment of disease caused by which of the following organisms?

Ascaris lumbricoides.
Trichuris trichiura.
Taenia saginata.
Strongyloides stercoralis.

Question 17 of 100

17. Question

Which of the following statements about Niridazole is correct?

The daily dose is 75mg/kg.
It is a known bone marrow depressant.
It is safe in liver disease.
Treatment for urinary schistosomiasis should last for 3–5 days. 218 B Because Niridazole can cause bone marrow depression, blood count checks are necessary where treatment is prolonged. The daily dose is 25mg/kg in two or three divided doses. It is contraindicated, especially in severe liver disease. If this drug must be used, treatment for urinary schistosomiasis should last for 7–10 days.

Question 18 of 100

18. Question

Diazepam: Which of the statements below is incorrect?

It is precluded in pregnancy.
If administered late in the second stage of labor, it may sedate the newborn.
In the elderly its use should be restricted and the dose reduced.
In early pregnancy it increases the risk of congenital abnormalities.

Question 19 of 100

19. Question

Digoxin: Which of the statements below is incorrect?

It should not be given intravenously.
In many cases it can be given orally with good results.
Doses of this drug may reach toxic levels if there is associated hypokalemia.
It should be used cautiously in association with a diuretic.

Question 20 of 100

20. Question

Acetylsalicylic acid: Which of the statements below is correct?

It has both analgesic and antipyretic properties.
It increases the synthesis of prostaglandins.
It is an ineffective musculoskeletal anti-inflammatory agent.
It may reduce or increase uric acid secretion.

Question 21 of 100

21. Question

Antibiotics: Which of the statements below is incorrect?

They are obtainable from bacteria.
They may be synthetic.
They can be derived from molds.
They do not interfere with bacterial cell wall synthesis.

Question 22 of 100

22. Question

With respect to Metronidazole which of the following statements is correct?

It is unnecessary to know a woman’s last menstrual period before prescribing it.
It may be freely prescribed to a lactating woman with a two-week old baby.
A dose of 800mg orally 8-hourly for five days is too high for an adult.
A dose of 40mg/kg/day divided 8-hourly is normal for children.

Question 23 of 100

23. Question

Which of the following statements pertaining to Piperazine is incorrect?

It acts by paralyzing helminths.
It is effective for the treatment of roundworm infestation.
It should not be used in patients with seizure disorder.
In the treatment of ascariasis it should be given to a 15-year-old child or an adult at a dose of 0.5g/day for two days.

Question 24 of 100

24. Question

Which of the following drugs may not be used in the treatment of schistosomiasis?

Metrifonate.
Oxamniquine.
Praziquantel.
Metronidazole.

Question 25 of 100

25. Question

Chlorpromazine: Which of the statements below is incorrect?

It is a major tranquilizer.
It is a piperazine phenothiazine.
It has a sedating effect.
It does not cause blood pressure changes.

Question 26 of 100

26. Question

Which of the following statements about emetine is incorrect?

It is derived from ipecachuana.
It is the drug of choice for treating amebic liver abscess.
It is a pyridoisoquinoline drug.
It is an antiprotozoal agent.

Question 27 of 100

27. Question

Adverse effects of acetylsalicylic acid: Which of the statements below is incorrect?

Respiratory alkalosis in adults and children.
Irritation of the gastrointestinal tract
Metabolic acidosis in children.
Decrease in the action of anticoagulants.

Question 28 of 100

28. Question

Which of the following statements about the use of Metronidazole is incorrect

There is a disulfiram-like effect when alcohol is taken concomitantly.
It effectively treats both intestinal amebiasis and amebic liver abscess.
Entamoeba histolytica cyst carriers and amebic colitis patients respond equally.
Proven anaerobic infections require treatment with its intravenous infusion.

Question 29 of 100

29. Question

Piperazine: Which of the following statements is correct?

It should be given to children at a dose of 75mg/kg/day for two days in ascariasis.
It does not treat pinworm infestation.
It should be taken after breakfast.
It has no gastrointestinal side effects

Question 30 of 100

30. Question

Praziquantel: Which of the statements below is correct?

It is the drug of choice for treating all species of Schistosomes.
It is not available for oral use.
It has an unsatisfactory safety profile.
It is associated with a poor cure rate for Schistosoma mansoni.

Question 31 of 100

31. Question

Chlorpromazine: Which of the statements below is correct?

It is not metabolized in the liver.
It commonly causes dependence.
It has a satisfactory ameliorating effect on delusions.
It may be given as a maintenance dose of 100mg/day

Question 32 of 100

32. Question

Which of the following is a manifestation of Digoxin toxicity?

Carpo-pedal spasms
Nausea and vomiting.
Shortened P-R interval.
Inverted Q waves.

Question 33 of 100

33. Question

Acetaminophen: Which of the statements below is correct?

It is a para-aminophenol precursor.
It is a metabolite of phenacetin.
It is a precursor of acetanilide.
It is available as tablets only.

Question 34 of 100

34. Question

Which of the following is not a side effect of Metronidazole?

Headache.
Metallic taste.
Nausea.
Retroperitoneal fibrosis.

Question 35 of 100

35. Question

Which of the following statements about Thiabendazole is incorrect?

It is structurally related to Mebendazole.
It may cause anorexia and vomiting.
It should be given to a 60kg patient at a dose of 1.5g/day for two days.
It is contraindicated in children confirmed to have helminthic infestations.

Question 36 of 100

36. Question

Trichomoniasis may be treated with which of the following drugs?

Furazolidone.
Mebendazole.
Thiabendazole.
Phthalylsulphathiazole.

Question 37 of 100

37. Question

Haloperidol: Which of the statements below is incorrect?

It is a neuroleptic.
It belongs to the butyrophenone group of drugs.
It is useful in manic patients and other agitated psychotics.
It rarely causes extrapyramidal side-effects.

Question 38 of 100

38. Question

Which of the following statements about treatment with digoxin is correct?

The plasma half-life is six hours.
It should be taken thrice daily because of its short half-life.
Following an oral dose the onset of action is expected within three hours.
It is excreted in the lungs.

Question 39 of 100

39. Question

Acetaminophen: Which of the statements below is correct?

It is absorbed satisfactorily in the gastrointestinal tract of children.
It is an anti-inflammatory agent.
It is an ineffective antipyretic.
It affects prostaglandin synthesis.

Question 40 of 100

40. Question

Metronidazole: Which of the statements below is correct

It is a nitrofuran.
It is very effective in treating infections caused by aerobic bacteria.
It is a good antiprotozoal drug.
It should not be used in treating luminal amebiasis.

Question 41 of 100

41. Question

Thiabendazole is effective for the treatment of which of the following?

Hookworm disease.
Schistosomiasis.
Trichuriasis.
Cutaneous larva migrans.

Question 42 of 100

42. Question

Which of the following drugs is ineffective for the treatment of giardiasis?

Chloroquine.
Metronidazole
Tinidazole.
Albendazole.

Question 43 of 100

43. Question

Haloperidol: Which of the statements below is correct?

It causes delirium tremens.
It causes severe hypotension.
It may be given at a dose of 25mg intramuscularly in acute cases.
It potentiates the effect of alcohol and diazepam.

Question 44 of 100

44. Question

Diuretics: Which of the statements below is correct?

Frusemide and ethacrynic acid are loop diuretics.
Triamterene and amiloride act at the proximal convoluted tubules.
Hyperuricemia is a side-effect of the distal tubular diuretics.
Potassium supplements must be taken during thiazide diuretic therapy.

Question 45 of 100

45. Question

Acetaminophen: Which of the statements below is correct?

It is excreted in the kidneys, mainly unchanged.
It is listed on the analgesic ladder for use in severe pain.
It is metabolized principally in the liver.
When accidentally taken as double dose, it causes liver necrosis.

Question 46 of 100

46. Question

Metronidazole is not useful for the treatment of which of the following?

Intra-abdominal infections.
Puerperal sepsis.
Post-abortal sepsis.
Leishmaniasis.

Question 47 of 100

47. Question

Which of the following drugs is not useful in the treatment of enterobiaisis?

Mebendazole.
Pyrantel pamoate.
Albendazole.
Metronidazole.

Question 48 of 100

48. Question

Benzyl benzoate: Which of the statements below is incorrect?

It is available as emulsion.
It is useful for treating scabies.
It may be used to treat pediculosis.
It is administered as a single dose.

Question 49 of 100

49. Question

Which of the following is not an adverse effect of phenothiazines?

Akathisia.
Oculogyric crises.
Myalgia of gluteal muscles.
Photosensitization.

Question 50 of 100

50. Question

Which of the following is a side effect of thiazide diuretics?

Hyperkalemia.
Hypernatremia.
Hyperuricemia.
Hypoglycemia.

Question 51 of 100

51. Question

Non-steroidal anti-inflammatory drugs: Which of the statements below is correct?

They are inorganic acids.
They do not affect prostaglandin synthesis.
Generally, they irritate the gastrointestinal tract.
They are not used in the treatment of acute gout.

Question 52 of 100

52. Question

Infections caused by which of the following organisms should not be treated with Metronidazole?

Trichomonas vaginalis.
Entamoeba histolytica.
Toxoplasma gondii.
Bacteroides species.

Question 53 of 100

53. Question

Which of the following anthelminthics acts by paralyzing worms?

Thiabendazole.
Pyrvinium pamoate.
Mebendazole.
Pyrantel pamoate.

Question 54 of 100

54. Question

Cyclophosphamide: Which of the statements below is correct?

It is an antimetabolite.
It is a drug of choice for treating Burkitt’s lymphoma.
It should not be used in General Hospitals but in Teaching Hospitals only.
It does not cause alopecia or vomiting.

Question 55 of 100

55. Question

Fluphenazine decanoate: Which of the statements below is incorrect?

It is a piperazine phenothiazine.
It is mild in potency.
It is useful for maintenance therapy in schizophrenia.
It is effective when given as monthly injections.

Question 56 of 100

56. Question

Hydralazine: Which of the statements below is incorrect?

It is a vasodilator.
It acts on the autonomic nervous system.
It can be administered orally.
When administered intravenously, it brings down a high blood pressure rapidly.

Question 57 of 100

57. Question

Diclofenac: Which of the statements below is incorrect?

It has satisfactory antipyretic and analgesic activities.
It is a weak inhibitor of the enzyme cyclo-oxygenase.
It should be taken preferably after meals
It is a known cause of headache.

Question 58 of 100

58. Question

Which of the following statements regarding treatment with Ivermectin is correct?

It may be used to treat intestinal strongyloidiasis.
It is not recommended for treatment of pediculosis.
Ivermectin is not useful for treating larval forms of Onchocerca volvulus.
Ivermectin is effective against adult Onchocerca volvulus.

Question 59 of 100

59. Question

Niclosamide: Which of the following statements is correct?

It is effective in treating paragonimiasis.
It effectively treats tapeworm infestations
It inhibits anaerobic metabolism in helminths.
It should be given to adults as a 0.5g single oral dose.

Question 60 of 100

60. Question

During treatment of trypanosomiasis with Suramin which of the following statements is correct?

Suramin 1g twice daily for two weeks is the maximum adult dose.
A standard dose of Suramin should be preceded by a test dose.
A dose of 50mg/kg in a day is satisfactory for children.
Recovery of the patient is expected irrespective of when treatment starts.

Question 61 of 100

61. Question

Tricyclic antidepressants do not include which of the following?

Amitriptyline.
Tranylcypromine.
Imipramine.
Doxepin

Question 62 of 100

62. Question

Which of the following relationships is correct?

Alpha-methyldopa and false neurotransmitter
Clonidine and Rauwolfia alkaloid.
Reserpine and neuroeffector blockade.
Guanethidine and alpha-receptor blockade.

Question 63 of 100

63. Question

Which of the following drugs is not a non-steroidal anti-inflammatory agent?

Piroxicam.
Ibuprofen.
Naproxen.
Trypsin-chymotrypsin.

Question 64 of 100

64. Question

Which of the following statements about treatment of onchocerciasis with diethylcarbamazine is correct?

It should be given at double-dose as in Brugia malayi infection.
A dose of 6mg/kg in three divided doses is adequate to treat the filariasis.
Duration of treatment is usually three days.
A test dose of 25mg twice in the day should be given on day 4 of treatment.

Question 65 of 100

65. Question

Of the following anthelminthics, what is the correct adult dose?

Pyrantel pamoate (Combantrin®), 750mg as a single dose.
Thiabendazole (MintezolTM), 1.5g b.i.d. for five days.
Mebendazole (Vermox®), 500mg b.i.d. for three days.
Albendazole (ZentelTM), 600mg as a single dose.

Question 66 of 100

66. Question

Melarsoprol: Which of the statements below is correct?

It is an organic base.
It may be given intravenously at a maximum dose of 10ml in a day.
The number of courses given to a patient depends on cerebro-spinal fluid load of trypanosomes.
The initial dose is 0.5ml intramuscularly.

Question 67 of 100

67. Question

Amitriptyline: Which of the statements below is incorrect?

It should be stopped if no definite positive effect is observed one week after starting treatment.
It should be used with a phenothiazine in an agitated depressed patient.
It is structurally related to the phenothiazines.
It should not be discontinued abruptly.

Question 68 of 100

68. Question

Side-effects of antihypertensives: Which of the statements below is incorrect?

Erectile dysfunction and alpha-methyldopa.
Orthostatic hypotension with alpha-methyldopa.
Erectile dysfunction and all antihypertensives that depress the sympathetic nervous system.
Tachycardia and atenolol.

Question 69 of 100

69. Question

Which of the following drugs may not be administered to a post-laparotomy patient in the immediate post-operative period after recovery from general anesthesia?

Acetaminophen parenterally.
Morphine injection.
Pentazocine injection.
Diclofenac orally.

Question 70 of 100

70. Question

Diethylcarbamazine may not be used to treat infection caused by which of the following?

Wuchereria bancrofti.
Loa-loa.
Brugia malayi
Trichinella spiralis.

Question 71 of 100

71. Question

What is the correct pediatric dose associated with the following anthelminthics?

Pyrantel pamoate 20mg/kg as a single dose.
Niclosamide 2g single dose for a 5-year-old child.
Mebendazole 100mg b.i.d. for three days for a 3-year-old child.
Levamisole 5mg/kg as a single dose.

Question 72 of 100

72. Question

Eflornithine: Which of the statements below is correct?

It is effective in treating stage 2 trypanosomiasis
It has a half-life of 18 hours.
It is metabolized by hydroxylation.
It is useful for treating excessive alopecia.

Question 73 of 100

73. Question

Unwanted effects of tricyclic antidepressants do not include which of the following?

Constipation.
Dryness of the mouth.
Tachycardia.
Hypertension.

Question 74 of 100

74. Question

Reserpine: Which of the statements below is incorrect?

It is a known cause of nasal stuffiness.
It is known to cause gynecomastia.
It does not control hypertension satisfactorily.
It may be given where other drugs are not readily available.

Question 75 of 100

75. Question

Which of the following statements about narcotic analgesics is incorrect?

They are potent analgesics.
They alter the patient’s perception of pain.
They may cause addiction.
The first post-operative dose should be given only when a patient complains of pain.

Question 76 of 100

76. Question

Side effects of diethylcarbamazine do not include which of the following?

Malaise.
Increased appetite.
Mazotti reaction.
Headache.

Question 77 of 100

77. Question

Praziquantel: Which of the following statements is correct?

It causes enzymatic lysis of the integument of schistosomes.
It should be administered intravenously for rapid onset of action.
It is given as a single 100mg/kg oral dose.
It is absorbed slowly from the gastrointestinal tract.

Question 78 of 100

78. Question

Which of the following statements about trypanosomicides is incorrect?

Nifurtimox may not be used in combination with eflornithine.
Fexinidazole is useful for treating both stage 1 and stage 2 of Human African trypanosomiasis.
Polyneuropathy is a side effect of Nifurtimox.
Benznidazole is effective in treating Chagas disease.

Question 79 of 100

79. Question

Which of the following statements about monoamine oxidase inhibitors is correct?

They are first-line drugs in the treatment of depression.
They decrease blood levels of catecholamines.
They cause a reduction in concentration of serotonin in blood.
They may cause insomnia and palpitations.

Question 80 of 100

80. Question

Atenolol may not be used for the treatment of which of the following?

Hypertension.
Depression.
Thyrotoxicosis.
Supraventricular arrhythmias.

Question 81 of 100

81. Question

Narcotic analgesics: Which of the statements below is correct?

They are sometimes synthetic drugs.
They are excluded from the “Dangerous Drugs Act” (DDA) group of drugs.
They are usually prescribed for out-patients.
They should be prescribed for patients whose headache has lasted more than 24 hours

Question 82 of 100

82. Question

Which of the following drugs may be used for the treatment of onchocerciasis?

Amodiaquine.
Metronidazole.
Ivermectin.
Oxamniquine.

Question 83 of 100

83. Question

Praziquantel is ineffective for the treatment of which of the following?

Schistosomiasis.
Diphylobothriasis.
Cutaneous larva migrans
Paragonimiasis.

Question 84 of 100

84. Question

Pentamidine: Which of the statements below is correct?

It is administered intravenously.
The drug crosses the blood-brain barrier.
It is useful in treating the hemolymphatic stage of trypanosomiasis.
Daily dose is 10mg/kg.

Question 85 of 100

85. Question

Which of the following drugs does not have anti-emetic properties?

Chlorpromazine.
Promethazine.
Diphenhydramine.
Acetaminophen.

Question 86 of 100

86. Question

Aminophylline: Which of the statements below is incorrect?

It is a theophylline derivative.
It causes bronchial smooth muscle relaxation.
It can be administered orally or intramuscularly.
It should be administered fast by the intravenous route.

Question 87 of 100

87. Question

Which of the following is an opiate?

Chlorpromazine.
Codeine.
Mefenamic acid.
Chloral hydrate.

Question 88 of 100

88. Question

Which of the following is not applicable to Praziquantel?

The pediatric formulation is available and very effective.
It is useful in implementation of preventive chemotherapy strategy for schistosomiasis.
It is a pyrazinoquinoline derivative.
Loose stools are recognized as side effects.

Question 89 of 100

89. Question

Niridazole: Which of the statements below is correct?

It disrupts spermatogenesis in sensitive helminths.
It is an intravenous drug.
It is given to an adult as 50mg/kg/day
It should be given to an adult in a dose not exceeding 750mg in a day.

Question 90 of 100

90. Question

Which of the following statements about Pentamidine is incorrect?

It may be used in place of Suramin in early trypanosomiasis.
It is ineffective in treating Trypanosoma brucei gambiense infections.
It should be administered with the patient lying down.
Glucose should be handy when a patient is undergoing treatment.

Question 91 of 100

91. Question

For treatment of generalized motor seizures which of the following statements is correct?

Phenytoin is useful.
Phenobarbital has no place
The patient should not be treated in the absence of drug blood level monitoring.
Ethosuximide is the drug of choice.

Question 92 of 100

92. Question

Which of the following drugs may not be used for treating asthma?

Theophylline
Epiandrosterone.
Prednisolone.
Racemic epinephrine.

Question 93 of 100

93. Question

Morphine: Which of the statements below is incorrect?

It provides satisfactory analgesia at a dose of 10mg intramuscularly.
It commonly causes addiction in the usual clinical doses and duration of therapy.
It causes psychological and physical dependence following prolonged use.
It causes hypotension if administered rapidly by the intravenous route.

Question 94 of 100

94. Question

Symptomless Entamoeba histolytica cyst passers may not be treated with which of the following drugs?

Chloroquine.
Diloxanide furoate.
Metronidazole.
Tinidazole.

Question 95 of 100

95. Question

Diethylcarbamazine: Which of the statements below is correct?

It is effective against adult Onchocerca volvulus.
It is available as 150mg tablets.
Therapy should be tailed down.
It kills both microfilariae and adults of Loa-loa.

Question 96 of 100

96. Question

Niridazole: Which of the statements below is correct?

It is an unsafe drug for children.
When used for the treatment of dracontiasis it should be administered for three days.
It is contraindicated in psychosis.
It may be used in seizure disorder.

Question 97 of 100

97. Question

Diazepam: Which of the statements below is correct?

It is a benzodiazepine.
It has a short plasma half-life, just three hours.
Its use does not require counseling the patient.
It should be used continuously for six months.

Question 98 of 100

98. Question

Which of the following statements about treatment of seizure disorders is incorrect?

Sodium valproate is effective in absence seizures.
Phenytoin is the drug of choice in generalized motor seizures.
Carbamazine is effective in partial complex seizures.
Diazepam has no place in status epilepticus.

Question 99 of 100

99. Question

In the therapy of asthma which of the following is indicated?

Salbutamol inhaler and not the tablets.
Ketotifen for short-term prophylaxis.
Humidified oxygen therapy during an acute asthmatic episode.
Disodium chromoglycate for acute asthma.

Question 100 of 100

100. Question

Which of the following is a side effect of morphine?

Mydriasis.
Constipation.
Intense cough.
Respiratory depression.